Background Among heterogeneous low density lipoproteinylAO, small dense LDL particles can penetrate vascular intima easier and they are more susceptible to oxidation in vitro These general characteristics are thought to make small dense LDL particles more atherogenic. And small dense LDL is known to be associated with coronary heart disease, but the
distribution of mean LDL particle- size is not well described in Koreans.
Methods LDL subfraction profiles in 93 Korean adult males were estimated by the UpoPrint LDL System(Quantimetrix Corp., Redondo Beach CA, USA). LDL subclass pattern were designated pattern A when mean LDL particle size was greater than 268A, pattern Bwhert it was smaller than 265A, and pattern l when it was between 265A and 268A.
Results The mean LDL particle size was 260±17AA Korean adult males and the prevalence of pattern A, pattern B, and pattern I were 30.1%, 39.8% and 30.1%, respectively. Mean LDL ´particle size showed negative correlation with serum concentrations of triglyceride(r=.0.667, PATOP and positive correlation with serum concentrations of HDL cholesterol(rOT479, P<0-001) but .had no significant correlation with the concentrations of cholesterol
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